|
AKI
|
Human
|
Plasma
|
miRNA
|
Circulating miR-210 predicts mortality of critically ill patients with AKI.
|
[28]
|
|
Human/mice (I/R)
|
Urine
|
miRNA
|
Urinary levels of miRNA-494 increased significantly before the rise in serum creatinine.
|
[29]
|
|
Mice (I/R)
|
Urine/serum
|
miRNA
|
Levels of urinary miR-10a and miR-30d were positively correlated with the degree of kidney injury induced by renal I/R.
|
[30]
|
|
Rat (Cisplatin)
|
Urine
|
miRNA
|
Eleven miRNAs were markedly changed in profiling experiment, which were involved with cisplatin-induced nephrotoxicity.
|
[31]
|
|
Mice (glycerol)
|
Blood
|
mRNA
|
MRNA from MSCs accelerated the morphologic and functional recovery of glycerol-induced AKI by inducing proliferation of tubular cells.
|
[32]
|
|
Mice (glycerol)
|
Blood
|
miRNA
|
MiRNA depletion in MSCs significantly reduced their intrinsic regenerative potential in AKI.
|
[33]
|
|
In vitro (ATP depletion)
|
Blood
|
miRNA
|
MiRNAs from MSCs were involved in recovery process in PTECs.
|
[34]
|
|
In vitro (Cisplatin)
|
Blood
|
mRNA
|
Transfer of IGF-1R mRNA from MSCs to cisplatin damaged proximal tubular cells increased cell proliferation.
|
[35]
|
|
CKD/fibrosis
|
Human/Mice (Alb/TGF-beta)/In vitro (TGF-beta1)
|
Plasma/Urine
|
miRNA
|
Specific urinary and plasma miRNA profile, such as Let-7a, miR-130a, miR-1825, miR-1281 and miR-423 were associated with declined eGFR and renal fibrosis.
|
[36]
|
|
Human
|
Blood/Urine
|
miRNA
|
Circulating levels of total and specific miRNAs were reduced in patients with severe CKD and strongly correlated with eGFR.
|
[38]
|
|
Mice (obstructive renal fibrosis)
|
Blood
|
miRNA
|
Bone marrow derived miR-144 protected the integrity of tubular basement membrane by inhibiting the activation of the tPA/MMP9-mediated proteolytic network.
|
[47]
|
|
Mice (obstructive renal fibrosis)
|
Kidney
|
mRNA
|
TGF-beta1 mRNA from injured epithelial cells constituted a rapid response to initiate tissue repair/regenerative responses and activation of fibroblasts.
|
[48]
|
|
Mice (obstructive renal fibrosis)
|
Kidney
|
miRNA
|
MiR-21 from injured tubular cells targeted PTEN protein and enhanced Akt signaling in recipient tubular cells.
|
[49]
|
|
Mice (obstructive renal fibrosis)
|
Kidney
|
miRNA
|
Secreted fibroblast miR-34a induced tubular cell apoptosis by targeting Bcl-2 protein.
|
[50]
|
|
PKD
|
Human
|
Urine
|
miRNA
|
Urinary miR-1, miR-133, miR-223 and miR-199 were dysregulated in ADPKD when compared to other CKD.
|
[51]
|
|
DKD
|
Human
|
Urine
|
mRNA
|
Urinary mRNA levels of CXCL9 and CXCL11 correlated with baseline eGFR. Urinary CXCL9 mRNA level was independently associated with the rate of GFR decline.
|
[53]
|
|
Human/Mice (STZ)
|
Urine
|
miRNA
|
Urinary exosomal miRNA content is enriched in type 1 diabetic patients with incipient diabetic nephropathy.
|
[54]
|
|
Human
|
Urine
|
miRNA
|
Urinary exosomal miR-320c and miR-6068 were altered in type 2 diabetic patients with DKD.
|
[55]
|
|
Human
|
Urine
|
miRNA
|
Urinary extracellular vesicle miR-192 may discriminate the normoalbuminuric group from the microalbuminuric group of type 2 diabetes patients.
|
[56]
|
|
LN
|
Human
|
Urine
|
miRNA
|
MiR-29c levels in urinary exosomes showed a negatively strong correlation with the histological chronicity index and glomerular sclerosis in patients with LN.
|
[57]
|
|
Human/Mice (autoimmune glomerulonephritis)
|
Urine
|
miRNA
|
Urinary exosomes miR-26a levels in B6.MRLc1 and patients with lupus nephritis were significantly higher compared with those for the respective healthy control.
|
[58]
|
|
Tumor
|
Human
|
Serum
|
miRNA
|
MiR-1233 was increased in serum of RCC patients.
|
[59]
|
|
Human
|
Blood
|
miRNA
|
The level of plasma miR-508-3p in RCC patients was significantly different from that in control.
|
[60]
|
|
Human
|
Urine
|
miRNA
|
The RNA ratio of miRNA-126: miRNA-152 in urine enabled the detection of urothelial bladder cancer.
|
[61]
|
|
Transplantation
|
Human
|
Urine
|
miRNA
|
The urinary miR-210 level identified patients with acute rejection and predicted long-term kidney function.
|
[62]
|
|
Human
|
Urine
|
mRNA
|
Urinary exosomal IL-18 mRNA was increased in CKD after transplantation.
|
[63]
|
