Skip to main content

Table 1 Overview of exRNA detection in renal diseases

From: Extracellular RNA in renal diseases

Disease Species/Model Specimen Type of RNA Results References
AKI Human Plasma miRNA Circulating miR-210 predicts mortality of critically ill patients with AKI. [28]
Human/mice (I/R) Urine miRNA Urinary levels of miRNA-494 increased significantly before the rise in serum creatinine. [29]
Mice (I/R) Urine/serum miRNA Levels of urinary miR-10a and miR-30d were positively correlated with the degree of kidney injury induced by renal I/R. [30]
Rat (Cisplatin) Urine miRNA Eleven miRNAs were markedly changed in profiling experiment, which were involved with cisplatin-induced nephrotoxicity. [31]
Mice (glycerol) Blood mRNA MRNA from MSCs accelerated the morphologic and functional recovery of glycerol-induced AKI by inducing proliferation of tubular cells. [32]
Mice (glycerol) Blood miRNA MiRNA depletion in MSCs significantly reduced their intrinsic regenerative potential in AKI. [33]
In vitro (ATP depletion) Blood miRNA MiRNAs from MSCs were involved in recovery process in PTECs. [34]
In vitro (Cisplatin) Blood mRNA Transfer of IGF-1R mRNA from MSCs to cisplatin damaged proximal tubular cells increased cell proliferation. [35]
CKD/fibrosis Human/Mice (Alb/TGF-beta)/In vitro (TGF-beta1) Plasma/Urine miRNA Specific urinary and plasma miRNA profile, such as Let-7a, miR-130a, miR-1825, miR-1281 and miR-423 were associated with declined eGFR and renal fibrosis. [36]
Human Blood/Urine miRNA Circulating levels of total and specific miRNAs were reduced in patients with severe CKD and strongly correlated with eGFR. [38]
Mice (obstructive renal fibrosis) Blood miRNA Bone marrow derived miR-144 protected the integrity of tubular basement membrane by inhibiting the activation of the tPA/MMP9-mediated proteolytic network. [47]
Mice (obstructive renal fibrosis) Kidney mRNA TGF-beta1 mRNA from injured epithelial cells constituted a rapid response to initiate tissue repair/regenerative responses and activation of fibroblasts. [48]
Mice (obstructive renal fibrosis) Kidney miRNA MiR-21 from injured tubular cells targeted PTEN protein and enhanced Akt signaling in recipient tubular cells. [49]
Mice (obstructive renal fibrosis) Kidney miRNA Secreted fibroblast miR-34a induced tubular cell apoptosis by targeting Bcl-2 protein. [50]
PKD Human Urine miRNA Urinary miR-1, miR-133, miR-223 and miR-199 were dysregulated in ADPKD when compared to other CKD. [51]
DKD Human Urine mRNA Urinary mRNA levels of CXCL9 and CXCL11 correlated with baseline eGFR. Urinary CXCL9 mRNA level was independently associated with the rate of GFR decline. [53]
Human/Mice (STZ) Urine miRNA Urinary exosomal miRNA content is enriched in type 1 diabetic patients with incipient diabetic nephropathy. [54]
Human Urine miRNA Urinary exosomal miR-320c and miR-6068 were altered in type 2 diabetic patients with DKD. [55]
Human Urine miRNA Urinary extracellular vesicle miR-192 may discriminate the normoalbuminuric group from the microalbuminuric group of type 2 diabetes patients. [56]
LN Human Urine miRNA MiR-29c levels in urinary exosomes showed a negatively strong correlation with the histological chronicity index and glomerular sclerosis in patients with LN. [57]
Human/Mice (autoimmune glomerulonephritis) Urine miRNA Urinary exosomes miR-26a levels in B6.MRLc1 and patients with lupus nephritis were significantly higher compared with those for the respective healthy control. [58]
Tumor Human Serum miRNA MiR-1233 was increased in serum of RCC patients. [59]
Human Blood miRNA The level of plasma miR-508-3p in RCC patients was significantly different from that in control. [60]
Human Urine miRNA The RNA ratio of miRNA-126: miRNA-152 in urine enabled the detection of urothelial bladder cancer. [61]
Transplantation Human Urine miRNA The urinary miR-210 level identified patients with acute rejection and predicted long-term kidney function. [62]
Human Urine mRNA Urinary exosomal IL-18 mRNA was increased in CKD after transplantation. [63]
  1. AKI Acute kidney injury, I/R Ischemia/reperfusion, MSC Mesenchymal stem cell, CKD Chronic kidney disease, Alb Albumin, TGF-beta Transforming growth factor-beta, eGFR Estimated glomerular filtration rate, tPA Tissue plasminogen activator, MMP9 Matrix metallopeptidase 9, PTEN Phosphatase and tensin homolog, Bcl-2 B-cell lymphoma 2, PKD Polycystic kidney disease, ADPKD Autosomal dominant polycystic kidney disease, DKD Diabetic kidney disease, CXCL C-X-C motif chemokine ligand, STZ Streptozosin, LN Lupus nephritis, RCC Renal cell carcinoma