Disease | Species/Model | Specimen | Type of RNA | Results | References |
---|---|---|---|---|---|
AKI | Human | Plasma | miRNA | Circulating miR-210 predicts mortality of critically ill patients with AKI. | [28] |
Human/mice (I/R) | Urine | miRNA | Urinary levels of miRNA-494 increased significantly before the rise in serum creatinine. | [29] | |
Mice (I/R) | Urine/serum | miRNA | Levels of urinary miR-10a and miR-30d were positively correlated with the degree of kidney injury induced by renal I/R. | [30] | |
Rat (Cisplatin) | Urine | miRNA | Eleven miRNAs were markedly changed in profiling experiment, which were involved with cisplatin-induced nephrotoxicity. | [31] | |
Mice (glycerol) | Blood | mRNA | MRNA from MSCs accelerated the morphologic and functional recovery of glycerol-induced AKI by inducing proliferation of tubular cells. | [32] | |
Mice (glycerol) | Blood | miRNA | MiRNA depletion in MSCs significantly reduced their intrinsic regenerative potential in AKI. | [33] | |
In vitro (ATP depletion) | Blood | miRNA | MiRNAs from MSCs were involved in recovery process in PTECs. | [34] | |
In vitro (Cisplatin) | Blood | mRNA | Transfer of IGF-1R mRNA from MSCs to cisplatin damaged proximal tubular cells increased cell proliferation. | [35] | |
CKD/fibrosis | Human/Mice (Alb/TGF-beta)/In vitro (TGF-beta1) | Plasma/Urine | miRNA | Specific urinary and plasma miRNA profile, such as Let-7a, miR-130a, miR-1825, miR-1281 and miR-423 were associated with declined eGFR and renal fibrosis. | [36] |
Human | Blood/Urine | miRNA | Circulating levels of total and specific miRNAs were reduced in patients with severe CKD and strongly correlated with eGFR. | [38] | |
Mice (obstructive renal fibrosis) | Blood | miRNA | Bone marrow derived miR-144 protected the integrity of tubular basement membrane by inhibiting the activation of the tPA/MMP9-mediated proteolytic network. | [47] | |
Mice (obstructive renal fibrosis) | Kidney | mRNA | TGF-beta1 mRNA from injured epithelial cells constituted a rapid response to initiate tissue repair/regenerative responses and activation of fibroblasts. | [48] | |
Mice (obstructive renal fibrosis) | Kidney | miRNA | MiR-21 from injured tubular cells targeted PTEN protein and enhanced Akt signaling in recipient tubular cells. | [49] | |
Mice (obstructive renal fibrosis) | Kidney | miRNA | Secreted fibroblast miR-34a induced tubular cell apoptosis by targeting Bcl-2 protein. | [50] | |
PKD | Human | Urine | miRNA | Urinary miR-1, miR-133, miR-223 and miR-199 were dysregulated in ADPKD when compared to other CKD. | [51] |
DKD | Human | Urine | mRNA | Urinary mRNA levels of CXCL9 and CXCL11 correlated with baseline eGFR. Urinary CXCL9 mRNA level was independently associated with the rate of GFR decline. | [53] |
Human/Mice (STZ) | Urine | miRNA | Urinary exosomal miRNA content is enriched in type 1 diabetic patients with incipient diabetic nephropathy. | [54] | |
Human | Urine | miRNA | Urinary exosomal miR-320c and miR-6068 were altered in type 2 diabetic patients with DKD. | [55] | |
Human | Urine | miRNA | Urinary extracellular vesicle miR-192 may discriminate the normoalbuminuric group from the microalbuminuric group of type 2 diabetes patients. | [56] | |
LN | Human | Urine | miRNA | MiR-29c levels in urinary exosomes showed a negatively strong correlation with the histological chronicity index and glomerular sclerosis in patients with LN. | [57] |
Human/Mice (autoimmune glomerulonephritis) | Urine | miRNA | Urinary exosomes miR-26a levels in B6.MRLc1 and patients with lupus nephritis were significantly higher compared with those for the respective healthy control. | [58] | |
Tumor | Human | Serum | miRNA | MiR-1233 was increased in serum of RCC patients. | [59] |
Human | Blood | miRNA | The level of plasma miR-508-3p in RCC patients was significantly different from that in control. | [60] | |
Human | Urine | miRNA | The RNA ratio of miRNA-126: miRNA-152 in urine enabled the detection of urothelial bladder cancer. | [61] | |
Transplantation | Human | Urine | miRNA | The urinary miR-210 level identified patients with acute rejection and predicted long-term kidney function. | [62] |
Human | Urine | mRNA | Urinary exosomal IL-18 mRNA was increased in CKD after transplantation. | [63] |