Fig. 3

Circulating miR-122 levels in PR hepatitis E patients presenting with different clinical manifestations. (a) miR-122 levels with respect to clinical manifestations. Scatter plots of serum miR-122 levels in NPR healthy individuals, NPR-C (n = 25), healthy PR women, PR-C (n = 33), PR acute hepatitis E patients, PR-HEV-acute (n = 40), PR women with subclinical HEV infection (PR-HEV-SC, n = 31), PR women bled one month later (PR-HEV-SC-repeat, n = 7). The line indicates the median value per group. Circulating miR-122 levels are expressed as log10 of miR-122 copies ml-1 serum. The Mann-Whitney U test was used to determine the statistical significance. p < 0.05 was considered to be significant. (b) and (c). Correlation of serum miR-122 and ALT levels in PR-HEV-acute (b) and PR-HEV-SC (c) patients. The correlation of serum miR-122 levels with serum ALT levels was determined by Spearman rank correlation coefficient. r indicates the correlation coefficient and p < 0.05 was considered significant