Fig. 2

Schematic diagram of lncARSR transfer mediated by exosomes. lncARSR was transmitted from sunitinib resistant cells to sunitinib sensitive cells and act as endogenous competing RNA for miR-34a and miR-449. The trapping of miR-34a and miR-449 by lncARSR thus increased the expression their targets AXL and c-MET, which is responsible for sunitinib resistance