Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance

ExRNA

Table 2 Deregulated miRNAs in pancreatic cancer and their functions in the EMT process

miRNAs	Targets	Status	Functions in the EMT process		Ref.
miRNAs	Targets	Status	Activation	Inhitibion	Ref.
miR-200a	ZEB1	down	TGF-β induced EMT Vimentin	P53 network E-cadherin	[126]
miR-200b	ZEB2/SIP1				[188]
miR-200c	Slug				[189]
miR-141	SIRT				[139]
miR-429					[142]
miR-126	ADM9	down	Cellular migration invasion	E-cadherin	[146]
miR-197	P120 catenin	up	EMT process		[147]
miR-205	ZEB2/SIP1	down		E-cadherin	[139]
Let-7	HMGA2	down	RAS signaling		[149, 150]
miR-217	SIRT1	down	TGF-β induced EMT		[151]
miR-203	SNAI1	down	EMT process		[152, 154]

ISSN: 2398-0060