Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance

ExRNA

Table 3 Deregulated miRNAs and their functions in pancreatic cancer stem cells

miRNAs	Targets	Status	Functions in CSCs		Ref.
miRNAs	Targets	Status	Activation	Inhibition	Ref.
miR-200a	Suz12	down	CD44 induction CSC formation CSC self-renewal	E-cadherin	[167]
miR-200b	Bmi 1				[169]
miR-200c	Notch 1				[168]
miR-141	Lin28B				[166]
miR-429	FoxM1				[145, 170, 171, 173]
miR-34a	HDAC1/2	down	cell migration invasion		[165]
miR-101	EZH2/MCL-1/Fos	down	cell proliferation invasion		[175]
miR-125b	BAK1	up		apoptosis	[178]
Let-7a	HMGA2	down			[152]

ISSN: 2398-0060