Fig. 1

Secreted microRNA in the tripartite neuromuscular junction. The neuromuscular junction has three different type cells: (1) muscle fiber and satellite cells; (2) axon terminals; (3) perisynaptic Schwann cells. The muscle specific miRNAs can be secreted via exosomes and diffuse to nerve terminal and/or perisynaptic Schwann cells where the exosomes are uptaken by these cells and play regulatory roles locally (arrow)