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Fig. 2 | ExRNA

Fig. 2

From: The disease-related biological functions of PIWI-interacting RNAs (piRNAs) and underlying molecular mechanisms

Fig. 2

The functional pathways of piRNA. (1) The PIWI-antisense piRNA complex cleaves sense transposon, piRNA precursor and protein-coding transcripts, the process of which leads to the suppression of transposon and gene expression. (2) PIWI-piRNA complex could suppress translation of target mRNA through imperfect binding to the 3’UTR region, a process similar to how miRNA functions. (3) PIWI-piRNA complex could enter the nucleus and influence DNA methylation level in the promoter region of target genes. “Me”, methylation

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ExRNA

ISSN: 2398-0060

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