microRNAs as therapeutic targets in intestinal diseases

ExRNA

Table 1 miRNA characteristics in CD patients

miRNA	Target gene(s)	Dysregulation	Function	Reference
miR-155	SOCS-1, JAK/STAT, SHIP-1	up	A negative regulator of lipopolysaccharide-induced macrophage activation and antigen presentation by dendritic cells	[21,22,23]
miR-196	IRGM	up	Affects autophagy efficacy	[24]
miR-124	Aryl hydrocarbon receptor	up	Promotes intestinal inflammation	[25]
miR-233	CLDN8	up	A mediator of the crosstalk between the CLDN8 and IL23 signal pathways	[26]
miR-30c	ATG5	up	Decreases autophagic activity and increases inflammation	[27]
miR-130a	ATG16L1	up	Decrease autophagic activity and increases inflammation	[27]
miR-301a	SMAD Nuclear Interacting Protein 1	up	Promotes Th17 cell differentiation	[28]
miR-31	IL25	up	Affects the mucosal IL-12/23-mediated Th1/Th17 pathway	[29]
miR-7	CD98	down	Provides a target for future therapeutic interventions	[30]
miR-210	HIF1a	down	A key transcription factor of Th17 polarisation	[31]
miR-141	CXCL12β	down	Influences immune cell recruitment, alters leukocyte trafficking	[32]

ISSN: 2398-0060