From: microRNAs as therapeutic targets in intestinal diseases
miRNA | Target gene(s) | Dysregulation | Function | Reference |
---|---|---|---|---|
miR-192 | MIP-2α | up | A master regulator of the inflammation process | [42] |
miR-126 | IκBα | up | Inhibits the NF-κB signalling pathway | [43] |
miR-155 | SOCS-1 | up | Protective in the context of infections, but pernicious in autoimmune disease | |
miR-150 | c-Myb | up | Increases mucosal leukocyte infiltration | [33] |
miR-124 | STAT3 | down | Inhibits STAT3 activation | [40] |
miR-214 | PDLIM2, PTEN | up | Induces NF-κB phosphorylation and subsequent IL-6 secretion | [46] |
miR-665 | XBP1, ORMDL3 | up | Promotes apoptosis and colitis | [47] |