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Table 1 Validated targets and proposed functions of HCMV-encoded miRNAs highlighted in this review

From: Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents

HCMV-encoded miRNA Target gene Functions References
hcmv-miR-UL112-3p MICB Immune evasion [27], [49]
IL-32 Immune evasion [50]
hcmv-miR-US4-1 ERAP1 Immune evasion [29]
hcmv-miR-UL112-5p ERAP1 Immune evasion [51]
hcmv-miR-UL112-3p IE72 Virus replication [24]
UL114 Virus replication [52]
hcmv-miR-US25-2 Undetermined Virus replication [52]
hcmv-miR-US25-1 Undetermined Virus replication [52]
hcmv-miR-US25-2 eIF4A1 Virus replication [53]
hcmv-miR-US25-1 ATP6V0C Virus replication [54]
hcmv-miR-US25-1 YWHAE, UBB, NPM1, HSP90AA1 Virus replication [55]
hcmv-miR-US33-5p STX3 Virus replication [56]
hcmv-miR-US5-1 Geminin Virus replication [57]
hcmv-miR-UL112-3p IE1 HCMV latency [59]
IE72 HCMV latency [60]
hcmv-miR-UL148D IER5 HCMV latency [61]
hcmv-miR-UL112-3p Type I IFNs Host secretory pathway [62]
TLR2 Host secretory pathway [63]
hcmv-miR-UL148D RANTES Host secretory pathway [65]
ACVR1B Host secretory pathway [66]
hcmv-miR-US25-1 CD147 Host secretory pathway [67]
hcmv-miR-UL148D IEX-1 Host cell apoptosis [68]
ERN1 Host cell apoptosis [70]
hcmv-miR-UL36-5p ANT3 Host cell apoptosis [73]
hcmv-miR-US4-1 QARS Host cell apoptosis [74]
hcmv-miR-US25-1 BRCC 3 Host cell apoptosis [75]
hcmv-miR-UL112-3p MAPK, Chemokine Host cell growth and proliferation [31]