Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents

ExRNA

Table 1 Validated targets and proposed functions of HCMV-encoded miRNAs highlighted in this review

HCMV-encoded miRNA	Target gene	Functions	References
hcmv-miR-UL112-3p	MICB	Immune evasion	[27], [49]
hcmv-miR-UL112-3p	IL-32	Immune evasion	[50]
hcmv-miR-US4-1	ERAP1	Immune evasion	[29]
hcmv-miR-UL112-5p	ERAP1	Immune evasion	[51]
hcmv-miR-UL112-3p	IE72	Virus replication	[24]
hcmv-miR-UL112-3p	UL114	Virus replication	[52]
hcmv-miR-US25-2	Undetermined	Virus replication	[52]
hcmv-miR-US25-1	Undetermined	Virus replication	[52]
hcmv-miR-US25-2	eIF4A1	Virus replication	[53]
hcmv-miR-US25-1	ATP6V0C	Virus replication	[54]
hcmv-miR-US25-1	YWHAE, UBB, NPM1, HSP90AA1	Virus replication	[55]
hcmv-miR-US33-5p	STX3	Virus replication	[56]
hcmv-miR-US5-1	Geminin	Virus replication	[57]
hcmv-miR-UL112-3p	IE1	HCMV latency	[59]
hcmv-miR-UL112-3p	IE72	HCMV latency	[60]
hcmv-miR-UL148D	IER5	HCMV latency	[61]
hcmv-miR-UL112-3p	Type I IFNs	Host secretory pathway	[62]
hcmv-miR-UL112-3p	TLR2	Host secretory pathway	[63]
hcmv-miR-UL148D	RANTES	Host secretory pathway	[65]
hcmv-miR-UL148D	ACVR1B	Host secretory pathway	[66]
hcmv-miR-US25-1	CD147	Host secretory pathway	[67]
hcmv-miR-UL148D	IEX-1	Host cell apoptosis	[68]
hcmv-miR-UL148D	ERN1	Host cell apoptosis	[70]
hcmv-miR-UL36-5p	ANT3	Host cell apoptosis	[73]
hcmv-miR-US4-1	QARS	Host cell apoptosis	[74]
hcmv-miR-US25-1	BRCC 3	Host cell apoptosis	[75]
hcmv-miR-UL112-3p	MAPK, Chemokine	Host cell growth and proliferation	[31]

ISSN: 2398-0060