TY - JOUR AU - Liu, Shanshan AU - Wang, Dandan AU - Liu, Yuan PY - 2019 DA - 2019/11/08 TI - Extracellular RNA in systemic lupus erythematosus JO - ExRNA SP - 33 VL - 1 IS - 1 AB - Since the discovery of extracellular RNA (exRNA), it has been shown that exRNAs play a significant role as a transducer in intercellular communication and biomarkers in various diseases. Systemic lupus erythematosus (SLE) is a kind of autoimmune disease that has protean manifestations. The survival and long-term prognosis of patients with SLE has improved in these 5–10 years, while disease pathogenesis is still not clear. Many researchers found the changes in exRNA profile, and exRNAs are likely participating in the process of SLE. In this review, we summarize the current profile and function of exRNA in SLE. Circulating miRNAs, in particular, have been identified as biomarkers for SLE diagnosis. We also explore the function of lncRNA in SLE and the potential correlation with disease progression and activity. These studies show that exRNAs may take parts in the process of SLE and some of them can be used as diagnostic tool for SLE. SN - 2398-0060 UR - https://doi.org/10.1186/s41544-019-0032-y DO - 10.1186/s41544-019-0032-y ID - Liu2019 ER -