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Table 2 The target genes and functions of miR-144 and miR-451 in tumorigenesis

From: miR-144/451 in hematopoiesis and beyond

miRNA Tumor type Target Function Reference
miR-451 B-cell lymphoma c-Myc suppressive [21]
miR-144 B-cell lymphoma BCL6 suppressive [37]
miR-451 T cell acute lymphoblastic leukemia c-Myc suppressive [34]
miR-451 multiple myeloma TSC1 suppressive [35]
miR-451 lung cancer c-Myc suppressive [66]
miR-451 lung cancer RAB14 suppressive [67]
miR-451 lung cancer Akt suppressive [68]
miR-451 lung cancer c-Myc suppressive [32]
miR-451 glioblastoma c-Myc suppressive [69]
miR-451 glioblastoma Cab39 Conditional switching control [70]
miR-451 glioblastoma Akt1 suppressive [71]
miR-451 glioblastoma N/Aa suppressive [52]
miR-451 breast cancer 14–3-3ζ suppressive [33]
miR-451 breast cancer MDR1   [72]
miR-144 colorectal cancer mTOR suppressive [73]
miR-451 colorectal cancer MIF suppressive [74]
miR-451 colorectal cancer MIF suppressive [75]
miR-451 colorectal cancer 14–3-3ζ suppressive [76]
miR-144 nasopharyngeal carcinoma PTEN oncogenic [77]
miR-451 nasopharyngeal carcinoma MIF suppressive [78]
miR-144 pancreatic carcinoma Notch-1 suppressive [79]
miR-144 insulinoma PTEN oncogenic [80]
miR-451 liposarcoma   suppressive [81]
miR-144/miR-451 breast cancer, head and neck carcinomas ADAMs ADAMs suppressive (invasion & metastasis) [42] [42]
miR-451 ovarian and cervix cancers MDR1 oncogenic [82]
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