miR-144/451 in hematopoiesis and beyond

ExRNA

Table 2 The target genes and functions of miR-144 and miR-451 in tumorigenesis

miRNA	Tumor type	Target	Function	Reference
miR-451	B-cell lymphoma	c-Myc	suppressive	[21]
miR-144	B-cell lymphoma	BCL6	suppressive	[37]
miR-451	T cell acute lymphoblastic leukemia	c-Myc	suppressive	[34]
miR-451	multiple myeloma	TSC1	suppressive	[35]
miR-451	lung cancer	c-Myc	suppressive	[66]
miR-451	lung cancer	RAB14	suppressive	[67]
miR-451	lung cancer	Akt	suppressive	[68]
miR-451	lung cancer	c-Myc	suppressive	[32]
miR-451	glioblastoma	c-Myc	suppressive	[69]
miR-451	glioblastoma	Cab39	Conditional switching control	[70]
miR-451	glioblastoma	Akt1	suppressive	[71]
miR-451	glioblastoma	N/A^a	suppressive	[52]
miR-451	breast cancer	14–3-3ζ	suppressive	[33]
miR-451	breast cancer	MDR1		[72]
miR-144	colorectal cancer	mTOR	suppressive	[73]
miR-451	colorectal cancer	MIF	suppressive	[74]
miR-451	colorectal cancer	MIF	suppressive	[75]
miR-451	colorectal cancer	14–3-3ζ	suppressive	[76]
miR-144	nasopharyngeal carcinoma	PTEN	oncogenic	[77]
miR-451	nasopharyngeal carcinoma	MIF	suppressive	[78]
miR-144	pancreatic carcinoma	Notch-1	suppressive	[79]
miR-144	insulinoma	PTEN	oncogenic	[80]
miR-451	liposarcoma		suppressive	[81]
miR-144/miR-451	breast cancer, head and neck carcinomas	ADAMs ADAMs	suppressive (invasion & metastasis)	[42] [42]
miR-451	ovarian and cervix cancers	MDR1	oncogenic	[82]

ISSN: 2398-0060