MicroRNAs and type 2 diabetes

ExRNA

Table 1 The functions of miRNAs

miRNAs	Mechanisms	Functions	Tissues
miR-29a and miR-29b	inhibit CAV2, INSIG1, PIK3R1	inhibit insulin signaling	liver
miR-126	inhibit IRS1	inhibit insulin signaling	liver
miR-223	inhibit GLUT4	inhibit glucose uptake	muscle
miR-33a and miR-33b	inhibit IRS2,SIRT6,AMPKa1	inhibit insulin signaling	liver
miR-130a	inhibit GRB10	promote insulin signaling	liver
miR-204	inhibit GLP1R	promote insulin signaling	pancreas
miR-378	inhibit p110a	inhibit insulin signaling	liver
miR-93	inhibit Sirt7,Tbx3	inhibit insulin signaling	null mice
miR-103 and miR-107	inhibit caveolin-1	inhibit insulin signaling	liver
miR-143	inhibit ORP8	inhibit insulin signaling	liver
Let7	inhibit IGF1R,INSR,IRS2	inhibit insulin signaling	muscle
miR-375	inhibit MTPN	reduce insulin secretion	pancreas
miR-124a	inhibit MTPN,FOXA2,RAB27A	reduce insulin secretion	pancreas
miR-9	inhibit OC2,SIRT1	reduce insulin secretion	pancreas
miR-29a and miR-29b	inhibit MCT1	reduce insulin secretion	pancreas
miR-184	inhibit AGO2	increase insulin secretion	pancreas
miR-122		liver injure and NAFLD	serum
miR-223		atherosclerosis	plasma
miR-126		type 2 diabetes	plasma
let7e		hypertension	plasma
miR-486, miR-146b and miR-15b		type 2 diabetes	serum
miR-199-3p		type 2 diabetes	plasma
miR-424	Keap1 and Nrf2	type 2 diabetes	serum
miR-146a		type 2 diabetes	plasma

ISSN: 2398-0060