Fig. 3

A summary of the regulatory role of miRNAs in generating innate immune response: briefly, the role of each miRNA in the figure is mentioned in the text. MiR-124 has inhibitory effects on Myd88, and miR-146a has an inhibitory effect on IRAK1 and TRAF6, all of them lead to activation of NFkB inflammatory pathway. On the other hand, let7-f with inhibitory effects on A20 protein can have inhibitory effects on the NFkB pathway. Other miRNAs, such as miR-99b and miR-125 directly affect the transcript of inflammatory cytokine mRNAs, such as TNF-α. A miRNA, such as miR-155, can have inhibitory effect on production of pre-inflammatory cytokines by the negative effect on SOCS1 and SHIP1