Table 1 MiRNAs and its regulatory effects on genes involved in immunity against M. tuberculosis
MiRNAs | The role of miRNA |
|---|---|
MiR-29 | Inhibition of interferon gamma (IFNγ) |
MiR-21 | Reduced expression of IL-1B IL-12P3 inhibition IL-10 increase inhibitory cytokine |
MiR-99b | Target TNF-α mRNA transcript |
MiR-125 | Target TNF-α mRNA transcript Reduce inflammatory responses |
MiR-155 | Target TNF-α mRNA transcript Inhibition of interferon gamma |
MiR-144 | Inhibition of interferon gamma and TNF-α |
MiR-223 | Inhibition of Interleukin 6 |
MiR-26a | Polarization induction of anti-inflammatory M2 macrophage phenotype. |