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Table 2 Pharmacokinetics analysis of plasma miR time curves after milk meal in healthy adultsa

From: MicroRNAs in bovine milk exosomes are bioavailable in humans but do not elicit a robust pro-inflammatory cytokine response

VariablemiR-15b-5pmiR-21-5pmiR-106b-5pmiR-223-3pmiR-1-3p
Baselineb, fmol/L682 ± 1502048 ± 190400 ± 110822 ± 12094 ± 9.8
Cmax, fmol/L1289 ± 3605048 ± 940b641 ± 1402152 ± 570a99 ± 4.9
% increasec89 ± 11.80147 ± 23.2060 ± 9.80162 ± 31.80
tmax, h3.7 ± 0.33.2 ± 0.64.1 ± 0.53.8 ± 0.7
AUCd, (fmol/L) × h3018 ± 120c12,669 ± 760c1531 ± 48c5377 ± 320c
  1. aValues are means ± SEM, n = 12. aP < 0.05, bP < 0.01, cP < 0.0001, vs. baseline. AUC Area under the plasma concentration versus time curve, Cmax Maximal plasma concentration, miR MicroRNA, tmax Time of peak concentration
  2. bPlasma concentration at time 0 h
  3. cCmax vs. baseline
  4. dFor hours 0–9