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Table 2 Pharmacokinetics analysis of plasma miR time curves after milk meal in healthy adultsa

From: MicroRNAs in bovine milk exosomes are bioavailable in humans but do not elicit a robust pro-inflammatory cytokine response

Variable

miR-15b-5p

miR-21-5p

miR-106b-5p

miR-223-3p

miR-1-3p

Baselineb, fmol/L

682 ± 150

2048 ± 190

400 ± 110

822 ± 120

94 ± 9.8

Cmax, fmol/L

1289 ± 360

5048 ± 940b

641 ± 140

2152 ± 570a

99 ± 4.9

% increasec

89 ± 11.80

147 ± 23.20

60 ± 9.80

162 ± 31.80

–

tmax, h

3.7 ± 0.3

3.2 ± 0.6

4.1 ± 0.5

3.8 ± 0.7

–

AUCd, (fmol/L) × h

3018 ± 120c

12,669 ± 760c

1531 ± 48c

5377 ± 320c

–

  1. aValues are means ± SEM, n = 12. aP < 0.05, bP < 0.01, cP < 0.0001, vs. baseline. AUC Area under the plasma concentration versus time curve, Cmax Maximal plasma concentration, miR MicroRNA, tmax Time of peak concentration
  2. bPlasma concentration at time 0 h
  3. cCmax vs. baseline
  4. dFor hours 0–9
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