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Table 1 Fuel preference for energy production in different segment of the kidney under physiologic and challenged conditions

From: Implications of microRNA in kidney metabolic disorders

Energy fuel preferenceProximal convoluted tubuleDistal convoluted tubuleThick ascending loopGlomeruliThin descending loopCollecting duct
Physiologic preferred fuelFatty acid
Lactate
Glutamine
Fatty acid
Ketones
Lactate
Fatty acid
Glucose
Ketones
Glucose
Lactate
Glucose
Lactate
Glutamine
Glucose
Use under challengeKetonesGlucoseLactateFatty acidKetonesLactate
Glutamine
Rarely useGlucoseGlutamineGlutamineKetones
Glutamine
Fatty acidFatty acid
Ketones