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Table 2 Regulation of miRNA on metabolic pathways

From: Implications of microRNA in kidney metabolic disorders

miRNATargetsMetabolic pathwaysReferences
miR-33CPT1αLipid metabolism[30, 31]
CROT[30, 31, 34]
3-ketoacyl-coA thiolase[31]
SIRT6[37]
AMPKα1[28, 55]
IRS2[37]
miR-370CPT1α[32]
miR-142[33]
miR-122aldolase-A[42]
miR-103, − 107PANK[45]
miR-224ACSL4[46]
miR-21PPARα[47, 48]
Mpv171[47]
miR-17PPARα[49]
miR-105MYC[50]
miR-199aPPARδ[52]
miR-29a[53]
miR-223GLUT4Glucose metabolism[63]
miR-106aGLUT3[21, 69, 70]
miR-195-5p[71]
miR-144GLUT1[72]
miR-1291[73]
miR-328[74]
miR-143HK2[75]
miR-155STAT3[76]
miR-124[77]
miR-128PFK[78]
miR-320[79]
miR-135[80]
miR-200cSIRT2[81]
Let-7PKM2, c-Myc[82]
miR-326PKM2[83]
miR-133a, −133b[84,85,86]
miR-122[87]
miR-26aPDHX[89]
miR-34LDHA[90, 91]
miR-375LDHB[92,93,94]
miR-124MCT1[95]
miR-342-3p[96]
miR-29INSIG1, PI3K subunit p85αGlycolytic related pathways[59]
CAV2[60, 61]
miR-126IRS1[62]
miR-103, −107CAV1[65]
miR-143ORP 8[67]
Let-7IGF1R, IRS2[68]
miR-340, − 124, − 137hnRNPI, hnRNPA1, hnRNPA2[88]
miR-410c-Met[97]
miR-144-3p[98]
miR-34a[99,100,101,102]
miR-34aPDGFRA[102]
miR-128PDGFRA, EGFR[103]
miR-219-5pEGFR[104, 105]
miR-7[106, 107]
miR-9NF1[108]
miR-143N-RAS[109]
miR-340[110, 111]
Let-7aK-RAS[112]
miR-134[113]
miR-7PI3K[114]
miR-542-3pAkt[115]
miR-21PTEN[116]
miR-26a[117]
miR-1908[118]
miR-494-3p[119]
miR-10a, −10b[120]
miR-21, − 221[121, 122]
miR-451CAB39[123, 124]
miR-199a-3pmTORC1, mTORC2[125]
miR-34aRictor[101, 126]
miR-34cc-Myc[127]
miR-155FoxO3a[128]
miR-193bSHMT2Amino acid metabolism[129]
miR-23a, 23bGlutaminase[130]
miR-29bDigydrolipoyl branched chain acyltransferase[131]
miR-1ND1, COX1Mitochondrial respiration and homeostasis[135]
miR-181cCOX1[140,141,142]
let7b, miR-146a, −133b, −106a, −19b, −20a, −34a, −181a, − 221Bcl-1[143, 144]
miR-378ATP synthase[145]
miR-1, −133aMef2A, Dik1-Dio3[146]
miR-388COX4[147]
miR-210ISCU, COX10[148, 149]
SDHD[150]
miR-355, −34aSOD2, TR2[151]
miR-25NADPH oxidase[152]
miR-26aPDHX[89]
miR-152, −148a, −148b, − 299, −19a, −19b, −122a, − 421, − 494CS[153]
miR-124SUCLG2[154]
miR-183IDH[155]
miR-743aMDH
miR-15b, −16, − 195, − 424ARL2[156]
miR-30p53[158]
miR-26UCP1[159]
miR-27a, −27bprohibitin[160]
miR-149PARP-1[161]
miR-378Caspase 3[162]
miR-1IGF[163]