Table 1 List of notable circRNAs and their roles in corresponding diseases
Disease | Notable Types | CircRNA | Function | References(PMID) |
|---|---|---|---|---|
Aging | Photoaging | circCOL3A1-859267 | Regulates type I collagen expression | 10902104 |
Cancer | Breast cancer | Circ-Foxo3 | Regulates cellular functioning of tissue cells | 14764598 |
15514005 | ||||
14796821 | ||||
Circ-ABCB10 | Sponges miR-1271 | 21566976 | ||
Colorectal cancer | hsa_circ_100219 | Expressed due to differentiation and perineural invasion | 19492553 | |
hsa_circ_0013958 | 17424658 | |||
hsa_circ_001988 | Overexpressed, potential biomarker | 19362625 | ||
hsa_circ_001569 | 29973005 | |||
circ-BANP | 19506007 | |||
Gastric cancer | Cdr1as | Plays antagonistic roles in regulating potential invasive liver cancer cells | 29969631 | |
circPVT1 | 20452322 | |||
hsa_circ_100269 | 18727980 | |||
circLARP4 | 13497006 | |||
Hepatocellular carcinoma | Cdr1as | Potential marker | Â | |
circRNA_000839 | MicroRNA sponge | 13421335 | ||
circRNA_100338 | 14230380 | |||
circZKSCAN1 | 20452322 | |||
Lung cancer Osteosarcoma | circ-ITCH | MicroRNA sponge | 18780261 | |
circUBAP2 | 29805712 | |||
hsa_circ_0016347 | 28977896 | |||
hsa_circ_0009910 | 19492553 | |||
10902104 | ||||
29255366 | ||||
Pancreatic carcinoma | circRNA_100782 | Â | Â | |
Cardiovascular | Atherosclerosis | Has_circ_0003575 | Inhibited angiogenesis ability of HUVECs | 19506007 |
Myocardial infarction | Cdr1as | miR-7a sponge | 19326203 | |
Diabetes | Diabetes | Cdr1as | Improves insulin production by inhibiting miR-7a | 20452322 |
22128778 | ||||
Hepatopathy | Liver fibrosis | hsa_circ_0071410 | MicroRNA sponge | 18790038 |
circRNA_021412 | ||||
Immune | Infection | circRasGEF1B | Regulates stability of mature ICAM-1 mRNA | 15558584 |
Neurological | Alzheimer’s disease | Cdr1as | Sponges miRNA-7 | 16648021 |
Diabetic retinopathy | circHIPK3 | Inhibits miR-124 activity | 00652598 | |
20411723 | ||||
Parkinson’s disease | Cdr1as | Sponges miRNA-7 | 27147959 | |
Skin, muscle and bone | Osteoarthritis | circRNA-CER | Promotes the degradation of chondrocyte ECM | 20452322 |
circRNA-MSR | 21622531 | |||
circRNA_Atp9b | 18790038 |