Table 3 Logistic regression analyses of biomarkers in predicting severe acute pancreatitis
Variables | Cutoff | Univariate analyses | Multivariate analyses | ||
|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | ||
Model 1a | |||||
miR-19a (×10−5) | 14 | 433.5 (46.4–4047.1) | < 0.001 | 69.2 (4.8–992.2) | 0.002 |
miR-143 (× 10− 5) | 58 | 272.0 (31.3–2364.8) | < 0.001 | 13.5 (0.7–244.8) | 0.078 |
miR-374-5p (× 10− 5) | 33 | NA | 0.997 | ||
CRP (mg/L) | 8 | NA | 0.997 | ||
Model 2b | |||||
miR-19a (×10−5) | 17 | 9.7 (3.3–28.0) | < 0.001 | ||
miR-143 (×10−5) | 88 | 11.6 (4.1–32.6) | < 0.001 | 18.1 (4.7–69.3) | < 0.001 |
miR-374-5p (×10−5) | 45 | 7.7 (2.9–20.5) | < 0.001 | ||
CRP (mg/L) | 36 | 18.2 (5.8–57.3) | < 0.001 | 11.5 (3.2–41.9) | < 0.001 |
Model 3c | |||||
miR-19a (×10−5) | 24 | 6.0 (1.9–18.6) | 0.002 | ||
miR-143 (×10−5) | 142 | 3.3 (1.3–8.3) | 0.012 | 6.8 (2.0–22.7) | 0.002 |
miR-374-5p (×10−5) | 63 | 3.9 (1.5–9.9) | 0.005 | ||
CRP (mg/L) | 114 | 4.5 (1.6–12.6) | 0.004 | 3.8 (1.4–10.6) | 0.011 |
Model 4d | |||||
miR-19a (×10−5) | 18 | 5.8 (2.5–13.3) | < 0.001 | ||
miR-143 (×10−5) | 101 | 6.4 (2.8–15.0) | < 0.001 | 4.5 (1.8–10.9) | 0.001 |
miR-374-5p (×10−5) | 50 | 5.7 (2.3–14.4) | < 0.001 | ||
CRP (mg/L) | 114 | 4.6 (2.0–10.4) | < 0.001 | 5.1 (2.1–12.4) | < 0.001 |