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Table 1 EV-associated ncRNAs in liver fibrosis

From: Role of ncRNAs in modulation of liver fibrosis by extracellular vesicles

 

ncRNAs

EV expression in hepatic fibrosis

Fibrosis model

Target genes in fibrosis

Functions

Citations

PRO-FIBROTIC

lncRNA-H19

↑ in EVs from damaged cholangiocytes

CLI

HMGA2, SHP

HSC activation, proliferation, differentiation, Biomarker of hepatic fibrosis

[157,158,159]

lncRNA-MALAT1

↑ in EVs from damaged hepatocytes

DILI

Col1α2, via miR-26b

HSC activation, Biomarker of hepatic fibrosis

[160]

miR-128-3p

↑ in EVs from damaged hepatocytes

NAFLD

PPAR-γ

HSC activation

[161]

miR-17-92 cluster

↑ in EVs from activated HSCs, damaged hepatocytes and plasma

ALD, HCV hepatitis

SOCS3, TGF-β signaling pathway

HSC activation, EMT, lipid metabolism, inflammatory responses, proliferation, apoptosis, necrosis

[162, 163]

ANTI-FIBROTIC

let-7s

↓ in EVs from activated HSCs and plasma

HCV hepatitis

TGF-β signaling pathway

Biomarker of hepatic fibrosis

[164]

miR-122

↑ in EVs from damaged hepatocytes ↑ in plasma EVs

↑ in EVs from engineered ADSCs

In vitro HSC activation, NASH, NAFLD, ALD, DILI,

HCV hepatitis

CCNG1, IGF1R, P4HA1

Survival, proliferation, EMT, fibrosis suppression biomarker of hepatic fibrosis

[161, 165,166,167,168,169,170]

miR-181-5p

↑ in EVs from engineered ADSCs

In vitro HSC activation, NASH

STAT3, Bcl-2, Beclin1

Fibrosis suppression

[171]

miR-192

↑ in plasma EVs

NAFLD,

HCV hepatitis

 

HSC activation, biomarker of hepatic fibrosis

[161, 165, 172]

miR-199a-5p

↑ in EVs from quiescent HSCs

In vitro HSC activation

CCN2

Adhesion, migration, proliferation survival and differentiation of HSCs

[173]

miR-214

↑ in EVs from quiescent HSCs, ↓ in EVs from activated HSCs and plasma

In vitro HSC activation

CCN2

Adhesion, migration, proliferation survival and differentiation of HSCs, Biomarker of hepatic fibrosis

[174, 175]

miR-22-3p, -26a-5p, -27b-3p, -302-3p, -486-5p, -92a-3p, -92b-3p

↑ in EVs from iPSCs,

In vitro HSC activation, NASH, BDL

TGF-β signaling pathway

Fibrosis suppression

[176]

miR-223

↑ in EVs from engineered BM-MSCs

AIH

NLRP3, caspase-1

Fibrosis suppression

[177]

miR-30a

↓ in EVs from activated HSCs

BDL

Beclin1

EMT, autophagy

[178]

miR-34c, -151-3p, -483-5p, -532-5p

↓ in serum EVs

NASH

PDGF, TIMP2, SMAD3 (predicted)

fibrosis suppression, biomarkers of hepatic fibrosis

[179]