From: MicroRNA’s in cancer as biomarkers and therapeutic keys
S. NO. | miRNA | REGULATION | CANCER | ROLE | AUTHOR | |
---|---|---|---|---|---|---|
1 | miR-10b | Up-regulated | Metastatic - Breast Cancer cells | Cell migration and Invasion nin Murine Xenograft | [23] | Breast Cancer |
2 | miR-21 | Up-regulated | Human Glioblastoma Tumor Tissue | Aggressive disease status: High tumor grade, negative hormone receptor status and ductal carcinoma | [24] | |
3 | miR-17-5p | Up-regulated | MDA-MB-231 Breast Cancer Cells | – | [25] | |
4 | miR-205 | Up-regulated | Breast Cancer cells | Prevents invasion, Proliferation and anchorage independent growth | [26] | |
5 | miR-17-5p | Down-regulated | MDA-MB-231 Breast Cancer Cells | Migration and Invasion | [25] | |
6 | miR-200 | Down-regulated | Invasive Breast cancer cells lines with mesenchymal phenotype | Drug resistance in Human Breast cancer | [27] | |
7 | miR-145 | Down Regulated | Breast Cancer Cells | Marker for early cancer diagnosis | [28] | |
miR-21 | Up-regulated | Esophageal Squamous Cell Carcinoma (ESCC) | – | [29] | ||
8 | miR-25 | Up-regulated | ESCC | Cell migration and Invasion directly | [30] | |
9 | miR-17-92 | Up-regulated | 75% of ESCC | Promote Cell Growth in vitro and In vivo | [31] | |
10 | miR-10b | Up-regulated | ESCC | Cell motility and Invasiveness | [32] | Esophageal Squamous Cell Carcinoma |
11 | miR-196a | Up-regulated | ESCC | Cell Proliferation and Anchorage independent growth and Suppress apoptosis | [33] | |
12 | miR-145 | FSCN1, novel target gene for miR-145, Upregulated | ESCC | Extensive tumor and Lymphnode metastasis and Poor prognosis | [34] | |
13 | miR-19a | Down Regulated | ESCC | Induce apoptosis in vitro and Impaired Tumor Growth in vivo | [31] | |
14 | miR-375 | Down-regulated | ESCC | Downregulates IGF1R | [35] | |
15 | miR-205 | Down regulated | ESCC | Increased Zinc Finger E-box binding homeobox 2 | [36] | |
16 | miR-21 | Up-regulated | GC | Oncomer in GC by inhibiting the tumor-suppressor genes PDCD4 and PTEN | Gastric Cancer | |
17 | miR-106a | Up-regulated | GC | down regulate IL10 expression | [40] | |
18 | miR-101 | Down Regulation | GC | Induce COX2 expression which activates activates the arachidonic acid/prostaglandin E2 pathway following cell proliferation | [41] |