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Table 1 microRNA expressions in different cancer cell/tumor

From: MicroRNA’s in cancer as biomarkers and therapeutic keys

S. NO.

miRNA

REGULATION

CANCER

ROLE

AUTHOR

 

1

miR-10b

Up-regulated

Metastatic - Breast Cancer cells

Cell migration and Invasion nin Murine Xenograft

[23]

Breast Cancer

2

miR-21

Up-regulated

Human Glioblastoma Tumor Tissue

Aggressive disease status: High tumor grade, negative hormone receptor status and ductal carcinoma

[24]

3

miR-17-5p

Up-regulated

MDA-MB-231 Breast Cancer Cells

[25]

4

miR-205

Up-regulated

Breast Cancer cells

Prevents invasion, Proliferation and anchorage independent growth

[26]

5

miR-17-5p

Down-regulated

MDA-MB-231 Breast Cancer Cells

Migration and Invasion

[25]

6

miR-200

Down-regulated

Invasive Breast cancer cells lines with mesenchymal phenotype

Drug resistance in Human Breast cancer

[27]

7

miR-145

Down Regulated

Breast Cancer Cells

Marker for early cancer diagnosis

[28]

 

miR-21

Up-regulated

Esophageal Squamous Cell Carcinoma (ESCC)

[29]

 

8

miR-25

Up-regulated

ESCC

Cell migration and Invasion directly

[30]

9

miR-17-92

Up-regulated

75% of ESCC

Promote Cell Growth in vitro and In vivo

[31]

10

miR-10b

Up-regulated

ESCC

Cell motility and Invasiveness

[32]

Esophageal Squamous Cell Carcinoma

11

miR-196a

Up-regulated

ESCC

Cell Proliferation and Anchorage independent growth and Suppress apoptosis

[33]

12

miR-145

FSCN1, novel target gene for miR-145, Upregulated

ESCC

Extensive tumor and Lymphnode metastasis and Poor prognosis

[34]

13

miR-19a

Down Regulated

ESCC

Induce apoptosis in vitro and Impaired Tumor Growth in vivo

[31]

14

miR-375

Down-regulated

ESCC

Downregulates IGF1R

[35]

15

miR-205

Down regulated

ESCC

Increased Zinc Finger E-box binding homeobox 2

[36]

16

miR-21

Up-regulated

GC

Oncomer in GC by inhibiting the tumor-suppressor genes PDCD4 and PTEN

[37,38,39]

Gastric Cancer

17

miR-106a

Up-regulated

GC

down regulate IL10 expression

[40]

18

miR-101

Down Regulation

GC

Induce COX2 expression which activates activates the arachidonic acid/prostaglandin E2 pathway following cell proliferation

[41]