Fig. 1

Distinct gut microbiome community structure differentiates WT and KO mice on chow diets. Analysis of 16S rRNA gene sequence data generated from fecal samples. a The lack of miR-146a expression in KO mice (dark red boxes) results in increased species richness and evenness when compared to WT mice (black boxes) as measured by the following alpha-diversity indices: observed species, Chao1, Shannon-diversity, and Simpson-diversity. Significance was determined by the Mann-Whitney U test; ***p < 001, ****p < 0001. b The Bray-Curtis dissimilarity measure was used to evaluate pairwise relationships between samples and data were plotted with nonmetric multidimensional scaling (NMDS). Each point represents an individual animal. c Taxonomic summary of percent relative abundance shows differential distribution of OTUs at the family-level phylogeny between WT and KO mice