From: Role of ncRNAs in modulation of liver fibrosis by extracellular vesicles
 | ncRNAs | EV expression in hepatic fibrosis | Fibrosis model | Target genes in fibrosis | Functions | Citations |
---|---|---|---|---|---|---|
PRO-FIBROTIC | lncRNA-H19 | ↑ in EVs from damaged cholangiocytes | CLI | HMGA2, SHP | HSC activation, proliferation, differentiation, Biomarker of hepatic fibrosis | |
lncRNA-MALAT1 | ↑ in EVs from damaged hepatocytes | DILI | Col1α2, via miR-26b | HSC activation, Biomarker of hepatic fibrosis | [160] | |
miR-128-3p | ↑ in EVs from damaged hepatocytes | NAFLD | PPAR-γ | HSC activation | [161] | |
miR-17-92 cluster | ↑ in EVs from activated HSCs, damaged hepatocytes and plasma | ALD, HCV hepatitis | SOCS3, TGF-β signaling pathway | HSC activation, EMT, lipid metabolism, inflammatory responses, proliferation, apoptosis, necrosis | ||
ANTI-FIBROTIC | let-7s | ↓ in EVs from activated HSCs and plasma | HCV hepatitis | TGF-β signaling pathway | Biomarker of hepatic fibrosis | [164] |
miR-122 | ↑ in EVs from damaged hepatocytes ↑ in plasma EVs ↑ in EVs from engineered ADSCs | In vitro HSC activation, NASH, NAFLD, ALD, DILI, HCV hepatitis | CCNG1, IGF1R, P4HA1 | Survival, proliferation, EMT, fibrosis suppression biomarker of hepatic fibrosis | ||
miR-181-5p | ↑ in EVs from engineered ADSCs | In vitro HSC activation, NASH | STAT3, Bcl-2, Beclin1 | Fibrosis suppression | [171] | |
miR-192 | ↑ in plasma EVs | NAFLD, HCV hepatitis |  | HSC activation, biomarker of hepatic fibrosis | ||
miR-199a-5p | ↑ in EVs from quiescent HSCs | In vitro HSC activation | CCN2 | Adhesion, migration, proliferation survival and differentiation of HSCs | [173] | |
miR-214 | ↑ in EVs from quiescent HSCs, ↓ in EVs from activated HSCs and plasma | In vitro HSC activation | CCN2 | Adhesion, migration, proliferation survival and differentiation of HSCs, Biomarker of hepatic fibrosis | ||
miR-22-3p, -26a-5p, -27b-3p, -302-3p, -486-5p, -92a-3p, -92b-3p | ↑ in EVs from iPSCs, | In vitro HSC activation, NASH, BDL | TGF-β signaling pathway | Fibrosis suppression | [176] | |
miR-223 | ↑ in EVs from engineered BM-MSCs | AIH | NLRP3, caspase-1 | Fibrosis suppression | [177] | |
miR-30a | ↓ in EVs from activated HSCs | BDL | Beclin1 | EMT, autophagy | [178] | |
miR-34c, -151-3p, -483-5p, -532-5p | ↓ in serum EVs | NASH | PDGF, TIMP2, SMAD3 (predicted) | fibrosis suppression, biomarkers of hepatic fibrosis | [179] |