Table 1 Extracellular miRNAs serve as the ligand for TLR7/8
miRNA | Source | Receipt cells | Cytokine | Ref |
|---|---|---|---|---|
miR-34a, −122, −133a, − 142, −146a, and -208a | plasma | macrophages and cardiomyocytes | MIP-2, TNF-α,IL-6 | Chao W et al [20] |
miR-29a | serum | Dendritic Cells | TNF-α, IL-6 | Garzon R et al [7] |
miR-let-7b | Rheumatoid Arthritis Synovial Fluid | macrophage | TNF-α, IL-8, IL-7 | Shahrara S et al [21] |
miR-21 | extracellular vesicles from the brains of rhesus macaques | macrophage/microglial cells | IL-6, TNF-α | Fox HS et al [22] |
miR-let-7c and − 21 | exosomes of the neuronal cultures and developing brains | neurons |  | Hsueh YP et al [23] |
miR-29b | exosomes from beta-cells | spleen cells | TNF-a | Bach JM et al [24] |
miRNA-let-7b | dorsal root ganglion neurons | dorsal root ganglion neurons | Â | Ji RR et al [19] |
miR-21 | lung cancer- and pancreatic cancer-derived microvesicles | myoblasts | Â | Croce CM et al [18] |
MicroRNA-146a | plasmacytoid dendritic cells | plasmacytoid dendritic cells | Â | Blom B et al [25] |
miR-21, − 147, and -29a | exosomes of cancer cells | macrophages | TNF-α, IL-6 | Croce CM et al [17] |
miR-let-7 | Cerebrospinal fluid | macrophage/microglial cells | TNF-α | Lehnardt S et al [8] |