Fig. 1
From: Co-targeting of EGFR by co-expressed miRNA-193a-3p/−5p in lung cancer
Inverse correlation of miRNA-193a-3p/−5p and EGFR protein expression levels in NSCLC tissues. a The relative expression levels of miRNA-193a-3p/−5p in 12 pairs of NSCLC and NAT samples. b Schematic description of the hypothetical duplexes between miRNA-193a-3p/−5p (bottom) and EGFR mRNA (top). The predicted free energy values were indicated. The conservation of miRNAs across species, including Homo sapiens (hsa), Mus musculus (mmu) and Macaca mulatta (mml), are displayed. c The relative luciferase activities that showing the binding abilities between miRNA-193a-3p/−5p and EGFR 3’UTR. WT: wild type; MUT: mutant. d EGFR protein levels in 12 pairs of NSCLC and NAT samples were analyzed by western blotting assays. Left panel: representative images; right panel: quantitative analysis. e EGFR mRNA levels in 12 pairs of NSCLC and NAT samples were analyzed by qRT-PCR. f The expression levels between miRNA-193a-3p/−5p and EGFR protein (left two panels) and between miRNA-193a-3p/−5p and EGFR mRNA (right two panels) in NSCLC tissues were analyzed by Pearson’s correlation scatter plot. *P < 0.05, **P < 0.01