microRNAs as therapeutic targets in intestinal diseases

ExRNA

Table 3 miRNA characteristics in CRC and CAC patients

miRNA	Target gene(s)	Dysregulation	Function	Reference
miR-21	PDCD4	up	Invasion, intravasation, metastasis, apoptosis, sensitivity to 5-FU	[49,50,51, 71]
miR-31	RASA1	up	Proliferation	[52]
miR-223	RASA1	up	Proliferation	[53]
miR-31	HIF1A, FIH1	up	Proliferation, metastasis, sensitivity to 5-FU	[54]
miR-143/145	MDM2, ERBB3, KLF5, BRAF, CD44	down	Proliferation, metastasis, death, chemosensitivity to 5-FU	[55,56,57,58,59]
miR-137	CDC42	down	Cell cycle and invasion	[60]
miR-34a	Axl, SIRT-1	down	Metastasis, chemosensitivity to 5-FU	[61, 64, 73]
miR-126	IRS-1, VEGF-A	down	Proliferation, migration and invasion, anti-angiogenic therapy	[62, 63]
miR-203	ATM kinase and AKT	down	Chemosensitivity to oxaliplatin	[65, 66]
miR-129	BCL2, TYMS	down	Apoptosis, cell growth, cell-cycle, sensitivity to 5-FU	[67, 68]
miR-502	RAB1B, p53	down	Autophagy, cell proliferation, cell cycle, tumour growth	[70]
miR-26b	E3 ubiquitin ligase DIP1	up	Cell death	[72]
miR-214	PDLIM2, PTEN	up	Malignant transformation	[46]
miR-18a	PIAS3	up	Proliferation, cell apoptosis	[75]

ISSN: 2398-0060