Fig. 2

Characterization of gut microbiomes from mice on chow or plant-based precision diets. a Observed species, Chao1, Shannon-diversity, and Simpson-diversity measures of microbiome sequence data from KO mice fed chow, vector, or miR-146a diets. Significance (*p < 0.05) was determined by the Mann-Whitney U test. b Bipartite network profile of mice on baseline chow diet (blue squares), plant-based vector diet (open green squares), and plant-based miR-146a diet (full green squares). c Bar graph of the mean abundance of genera with means > 0.01 abundance in at least one diet group. Error bars represent standard deviation (95% confidence). d Bipartite network comparisons of mice on vector (open green squares) and miR-146a (closed green squares) diets. Gray circles and edges represent the genera and genera-OTU abundances, respectively, for both (b) and (d). e Heatmap visualization of paired p-values from t-tests comparing 1) chow vs vector, 2) chow vs miR-146a, and 3) vector vs miR-146a diets for the genera shown in (c)