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The small RNA (sRNA) landscape of mammalian spermatozoa is considerably altered as these gametic cells migrate through the segment specific microenvironments of the epididymis. More specifically, the microRNA ...
Given the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus 2 (nSARS-CoV-2) infection pandemic situation, research to repurpose drugs, identify novel drug targets, vaccine candidates ...
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression at the posttranscriptional level and play a crucial role in development and many diseases. The discovery of miRNAs has greatly expande...
Many factors are involved with cellular differentiation and pluripotency, such as long non-coding and microRNAs (miRNA). miR-720 has been demonstrated to affect development, differentiation and pluripotency in...
Small non-coding RNAs (sRNAs) are regulatory molecules, present in all forms of life, known to regulate various biological processes in response to the different environmental signals. In recent years, deep se...
Small (s) RNA molecules are crucial factors in the communication between hosts and their interacting pathogens/pests that can modulate both host defense and microbial virulence/pathogenicity known as cross-kin...
Global estimations of 4 billion people living on plant-based diets signify tremendous diversity in plant consumption and their assorted miRNAs, which presents a challenging model to experimentally address how ...
Dysregulated microRNAs (miRNAs) have been identified to be associated with various diseases. However, the relationship between serum miRNAs and the severity of acute pancreatitis (AP) remains unknown.
MicroRNA (miRNA), the noncoding RNAs, are short length with 22 nucleotides. It involved in various biological process. Its expression is found varied in cancer and hence used as a marker. miRNAs are become imp...
MicroRNAs play key roles in host-pathogen-interactions and disease pathogenesis. Our aim was to characterize the differentially expressed miRNAs in the blood cells of diseased (Brucellosis-positive, Johne’s di...
Extracellular vesicles (EVs) are small membrane vesicles carrying bioactive lipids, proteins and nucleic acids of the cell of origin. In particular, EVs carry non-coding RNAs (ncRNAs) and the vesicle membrane ...
Oral squamous cell carcinomas (OSCC) secrete exosomes into the surrounding extracellular environment to promote the horizontal transfer of bioactive molecules including microRNA (miRNA). The primary objective ...
Following improvement and integration of novel genome sequencing techniques, a new stage light has been shone upon circular RNAs (circRNA) in regard to their structure and functionality. In comparison to their...
The kidney requires large amount of energy to regulate the balance of fluid, electrolytes and acid-base homeostasis. Mitochondria provide indispensible energy to drive these functions. Diverse energy sources s...
Potyviridae is the largest plant infecting family under the monophyletic group Riboviria, infects many of the food, fodder and ornamental crops. Due to the higher mutation and recombination rate, potyvirids are e...
Neolamarckia cadamba (Roxb.) Bosser (Rubiaceae) is a widespread plant with medicine value and has been used for treating various diseases, such as coughs, fevers, anemia, blood disorders and stomach pains. It had...
Bovine milk exosomes are studied for their roles as bioactive food compounds and as vehicles for drug delivery. Both lines of investigation converge on immune function, e.g., immune regulation by absorption of...
MicroRNAs (miRNAs) function as important oncogenes or tumor suppressors in each stage of cancer development. While previous studies focused on the individual miRNA and its specific target gene, the cooperative...
Lung cancer is the major cause of cancer-related deaths globally. Mutant KRAS is a feature of 15–50% of lung cancer cases and represents one of the most prevalent oncogenic drivers in this disease. Unfortunate...
Long noncoding RNAs (lncRNAs) play critical roles in eukaryotic gene regulation and diseases, rather than being merely transcriptional “noise”. Over the past decade, the study of lncRNAs has emerged as a burge...
MicroRNAs are non-coding RNAs, playing an important role in regulating many biological pathways, such as innate immune response against various infections. Different studies confirm that many miRNAs act as imp...
Since the discovery of extracellular RNA (exRNA), it has been shown that exRNAs play a significant role as a transducer in intercellular communication and biomarkers in various diseases. Systemic lupus erythem...
Neuroinflammation can be induced under several conditions including pathogen infection such as virus. As the main immune cells in brain, microglia activation plays a pivotal role in neuroinflammation by respon...
Procambarus clarkii is one of the important economic species in China and has been served as tasty food in recent years after being introduced to Nanjing. Significant problems of environment factors, such as sali...
MicroRNAs (miRNAs) are a number of small non-coding RNAs playing a regulatory part in gene expression. Many virus-encoded miRNAs have been found, which manifests that viruses as well apply the basic pattern of...
The discovery of small non-coding RNAs, such as miRNA and piRNA, has dramatically changed our understanding of the role RNA plays in organisms. Recent studies show that a novel small non-coding RNA generated f...
Circulating microRNAs (miRNAs) are exceptionally stable molecule markers in extracellular environments for various diseases. Importantly, some circulating miRNAs that were encapsulated in extracellular microve...
Houttuynia cordata Thunb (Family: Saururaceae) is well known as a traditional medicine plant and widely spread in China, Japan and India. It had been reported to have potential functions such as anti-bacterial, a...
Ribonucleic acids (RNAs) mainly played auxiliary roles in regulations of genetic processes while recent explorations into small non-coding RNAs (sRNAs) in bacteria have broadened the scope of RNAs studies in t...
Intestinal diseases, which primarily include inflammatory bowel disease (IBD), colorectal cancer (CRC) and colitis associated cancer (CAC), are believed to develop as a result of heredity transmit, autoimmune ...
Circulating microRNAs (miRNAs) have been recognized as novel molecular markers for renal cell carcinoma (RCC) diagnosis. However, the clinical impact of circulating miRNA has rarely been evaluated for the earl...
MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate posttranscriptional regulation. Based on the level of sequence complementarity, miRNAs lead to the degradation of target mRNAs or ...
Dampening of patients’ immune response to tumor-specific antigens is a major reason for tumor development and progression. Within tumor microenvironment, aberrant expression of immune checkpoints changes T lym...
Mounting evidence show that miRNAs are loaded into exosomes and secreted by almost all types of cells. miRNAs are selectively sorted into exosomes, and transferred to recipient cells, where they manipulate cel...
More than a decade ago, PIWI-interacting RNA (piRNA) was discovered almost simultaneously by four different research groups. The length of this type of single stranded noncoding RNA is 24~31 nucleotides (nt), ...
Extracellular RNA (exRNA) is a type of RNA fragment that presents in extracellular fluids with highly stable features. It is carried by vesicles, such as exosomes, apoptotic bodies and other microvesicles, or ...
microRNAs are small, non-coding, single-stranded RNAs that can suppress mRNA translation at the posttranscriptional level by binding to imperfect complementary sequences on mRNA targets and then cause their de...
MicroRNAs (miRNAs) are non-coding single strand RNAs. MiRNAs are encoded by endogenous genes with a length of about 22 nucleotides. MiRNAs play a vital role in the inhibition of post-transcriptional translatio...
Over the past decade, small non-coding RNAs (sRNAs) have been characterized as important post-transcriptional regulators in bacteria and other microorganisms. Secretable sRNAs from both pathogenic and non-path...
Although microRNA (miRNA) regulation is widely considered as a mechanism to regulate gene expression in metazoans, plants and viruses, there are recent reports that show the interaction between viruses and the...
MicroRNAs (miRNAs), a class of 18–25 nucleotide (nt) non-coding RNAs, usually inhibit the expression of their target genes. They are transcribed from endogenous genes and are processed for maturation by multip...
Honeybee caste differentiation is regulated by multiple factors. Here we comment an article published on August 31, 2017, Plos Genetics, which show that miRNAs from pollen may affect honeybee caste formation. ...
Mature microRNAs (miRNAs) are 18–24-nucleotide non-coding RNAs with post-transcriptional regulatory functions and have been documented as an essential cornerstone of the genetic system. Although the traditiona...
Pancreatic cancer (PaC) is one of the most aggressive malignancies. The dismal survival rate of PaC patients is mainly due to the late diagnosis and their resistance to conventional chemotherapies. Emerging ev...
MicroRNA isoforms are the variants of a canonical miRNA-sequence with alteration at the 3` or 5` termini due to addition, deletion and/or substitution of nucleotide. The present study aims at identifying the i...
MicroRNAs are small non-coding RNAs containing about 18–25 nucleotides which modulate gene expression post-transcriptionally. Recently, microRNAs have been detected in the extracellular space including a wide ...
MicroRNAs (miRNAs) are small single stranded non-coding RNAs that performed significant role in post-transcriptional regulation of target gene product. They are typically conserved among the organisms and also...
The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms. Importantly, thes...
RNA interfering (RNAi) is mediated by small non-coding RNAs (sRNAs) and efficiently silence gene expression at the posttranscriptional level in eukaryotes. In addition to functioning within a cell, such silenc...
MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs)...